Articles

Elsevier,

Pharmacological Research, Volume 211, January 2025, 107563

The article discusses the discovery of the A673V mutation in the amyloid precursor protein (APP) gene, which is associated with the familial form of Alzheimer's disease (AD) in a homozygous state. It provides an in-depth review of the molecular insights and therapeutic potential of the A?A2V peptide, including the development of a neuroprotective peptide A?1-6A2V(D) that inhibits amyloid-? aggregation and toxicity in preclinical models of AD and primary tauopathies

Elsevier,

Results in Engineering, Volume 25, 2025, 103867

The authors propose a multi-attribute group decision-making (MAGDM) approach to evaluate and select digital voting tools that facilitate public participation in urban transport decision-making.

Elsevier

When women who are taking thyroid hormones become pregnant, they are often requested to take double the dosage immediately. Read the study to learn proper dosage and timing for pregnant women taking thyroid hormones.

Elsevier

This article highlights the efforts and successes of the Chemistry Women Mentorship Network (ChemWMN) in the US, a structured mentorship network open to all woman-identifying individuals in chemistry interested in advancing in the academic landscape.

Elsevier

This review synthesizes the latest evidence on the epidemiology, screening, and treatment of osteoporosis in men, with a focus on genetic, environmental, and epidemiological disparities between Eastern and Western populations.

Elsevier,

Polar Science, Volume 42, December 2024

This research article presents a comprehensive review of the snow cover area, mass balance, glacial area loss, surface velocities, and the application of snowmelt runoff models in the Kashmir Himalayas and Upper Indus Basin. It finds that glaciers in these regions are experiencing significant ice loss and negative mass balance, with broader implications for water resources and ecosystems as climate change accelerates.
Elsevier,

Polar Science, Volume 42, December 2024

This study investigates variations in the ice-flow speed of the Shirase Glacier ice tongue in East Antarctica from July 2018 to December 2021 using Sentinel-1 radar imagery. It identifies significant slowdown events linked to icebergs grounding on the seafloor, revealing that the ice tongue provides limited support to the grounding line, which has broader implications for understanding glacier dynamics and the potential consequences of ice loss in the context of climate change.
Elsevier,

hLife, Volume 2, December 2024

The article provides a comprehensive overview of the Keystone Symposia conference on Myeloid Cell Diversity, highlighting key presentations on topics such as phagocytosis of dead cells, neutrophil behavior, myeloid cell states, and the impact of lifestyle factors on myeloid cells in disease states. It also discusses the role of myeloid cells in Alzheimer's disease, specifically how their dissociation may mediate vascular dysfunction.
Elsevier,

Acta Pharmaceutica Sinica B, Volume 14, December 2024

The article describes the development of a self-regulated multi-functional nano-modulator (siR/PIO@RP) that can intelligently navigate to the damaged blood-brain barrier and release therapeutic cargoes for synergetic Alzheimer's disease (AD) therapy. The nano-modulator is capable of reducing cerebral amyloid-β load, relieving neuroinflammation, and alleviating the dysfunction of the neurovascular unit, providing proof of concept that normalizing the neurovascular unit holds promise as a means of alleviating AD symptoms.

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