Articles

Elsevier,

One Earth, Volume 4, 19 February 2021

Highlights issues to be aware of when designing adaptation policy and calls for greater attention to the social justice implications in the policy design process.
Schematic representation of the mechanism by which readthrough compounds restore channel function in G542X-CFTR–expressing cells. PTC refers to the premature termination codon.
Elsevier,

SLAS Discovery, Volume 26, February 2021

Cystic fibrosis (CF) is caused by a mutation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, which disrupts an ion channel involved in hydration maintenance via anion homeostasis. Nearly 5% of CF patients possess one or more copies of the G542X allele, which results in a stop codon at residue 542, preventing full-length CFTR protein synthesis. Identifying small-molecule modulators of mutant CFTR biosynthesis that affect the readthrough of this and other premature termination codons to synthesize a fully functional CFTR protein represents a novel target area of drug discovery. We describe the implementation and integration for large-scale screening of a homogeneous, 1536-well functional G542X-CFTR readthrough assay. The assay uses HEK 293 cells engineered to overexpress the G542X-CFTR mutant, whose functional activity is monitored with a membrane potential dye. Cells are co-incubated with a CFTR amplifier and CFTR corrector to maximize mRNA levels and trafficking of CFTR to the cell surface. Compounds that allow translational readthrough and synthesis of functional CFTR chloride channels are reflected by changes in membrane potential in response to cAMP stimulation with forskolin and CFTR channel potentiation with genistein. Assay statistics yielded Z′ values of 0.69 ± 0.06. As further evidence of its suitability for high-throughput screening, we completed automated screening of approximately 666,000 compounds, identifying 7761 initial hits. Following secondary and tertiary assays, we identified 188 confirmed hit compounds with low and submicromolar potencies. Thus, this approach takes advantage of a phenotypic screen with high-throughput scalability to identify new small-molecule G542X-CFTR readthrough modulators.
Elsevier,

The Lancet Public Health, Volume 6, February 2021

An article on the long-term risk of dementia, in the context of SDG 3, focusing specifically on the association between dementia onset and reduced participation in cognitive and social activities.
Elsevier,

Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, Volume 239, January 2021

Trichlorfon is an organophosphate pesticide used extensively for controlling ectoparasites in aquaculture. Studies have found that trichlorfon caused environmental pollution and severe neurotoxic effects in several freshwater species. Feed additives such as flavonoids may reduce or prevent pesticide-induced toxicity in fish. The aim of the present study was to determine whether acute exposure to trichlorfon impairs behaviour and causes oxidative damage in brains of silver catfish (Rhamdia quelen).
Elsevier, International Review of Research in Developmental Disabilities, Volume 61, January 2021
Substantial systemic barriers to care exist for Black, Latino, Asian, and other communities of color, as well as low-resourced populations. Yet, few parent-mediated or parent education interventions specifically target ethnically, racially, or socioeconomically diverse families of children with autism spectrum disorder and/or intellectual and developmental disabilities (ASD/IDD). Furthermore, the ASD/IDD literature is lacking guidance on methods to culturally adapt interventions to attend to families' unique strengths and challenges.
Elsevier, Advances in Child Development and Behavior, Volume 60, January 2021
Research conducted over the last century has suggested a role for sleep in the processes guiding healthy cognition and development, including memory consolidation. Children with intellectual and developmental disabilities (IDDs) tend to have higher rates of sleep disturbances, which could relate to behavior issues, developmental delays, and learning difficulties.
Elsevier,

International Review of Research in Developmental Disabilities, Volume 61, January 2021

Children and youth with intellectual and developmental disabilities (I/DD) are at increased risk for obesity, metabolic syndrome, type 2 diabetes, hypertension, hyperlipidemia, and a host of other co-morbidities. By adulthood, this population is at very high risk for multiple co-morbidities that significantly shorten life expectancy and have negative impact on quality of life. Despite these disparities, children and youth with I/DD have limited access to resources and opportunities to engage in programming that appropriately address their needs.

Elsevier,

American Journal of Clinical Nutrition, Volume 113, 1 January 2021

In this special article, the authors call for nutrition scientists to collaborate with other sectors, disciplines, and experts to develop a more nuanced understanding of how specific shifts in food systems can have broad impacts on sustainability and to bring about food policy changes in the era of climate disruption and environmental degradation.
Elsevier,

International Review of Research in Developmental Disabilities, Volume 61, January 2021

People with disabilities, including individuals with intellectual and developmental disabilities (IDD), experience unique circumstances that alter their risk for and experiences of violence and abuse. In particular, people with disabilities may be at risk for two forms of disability-related abuse: (1) denial of assistance with activities of daily living (e.g., eating, dressing, toileting) and (2) denial of assistive technology (e.g., mobility aids, medical devices, communication devices).

Elsevier,

EClinicalMedicine, Volume 31, January 2021

An Editorial in support of SDGs 3, 9, and 13, focusing specifically on how to apply the lessons learned in public health during the COVID-19 pandemic to an equitable and sustainable recovery from the climate crisis.

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