Elsevier,
The Lancet Global Health, Volume 11, August 2023
This Article supports SDG 3 by showing that short-course tuberculosis preventive treatment is likely to be cost-effective (compared with no tuberculosis preventive treatment) for adult contacts in 15 countries and people living with HIV/AIDS in seven countries, even under conservative cost-effectiveness thresholds.
Elsevier,
The Lancet HIV, Volume 10, August 2023
This Article supports SDG 3 by showing that men who have sex with men (MSM) in Africa remain highly vulnerable to HIV acquisition and HIV-related mortality and morbidity, undermining the Global AIDS Strategy to end AIDS; realising the UNAIDS 95-95-95 targets and reducing disparities in HIV incidence requires urgent efforts to strengthen community-led prevention efforts.
Elsevier,
Engineering Applications of Artificial Intelligence, Volume 123, August 2023
Using brain tissue from donors with Alzheimer's disease, Anderson et al. identify new links between gene regulation and disease. These regulators could represent future clinical targets or disease markers for Alzheimer's diagnosis and treatment.
eClinicalMedicine, Volume 62, August 2023
Population-based surveys are expensive and time consuming. By determining state-level seropositivity using national testing service data and a Bayesian linear model, a map of HIV prevalence was generated across the whole of Nigeria. By identifying the areas in which HIV is most prevalent interventions can be targeted. This less resource intense Bayseian method allows for national monitoring of HIV prevalence.
Elsevier,
Free Radical Biology and Medicine, Volume 204, 1 August 2023
In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.
The Lancet Regional Health - Southeast Asia, Volume 15, August 2023
The short comment supports SDGs 12 and 13 and advocates the concept of LIFE that focusses on an individual's responsibility to utilise resources mindfully and contribute their share to saving the planet. This concept was introduced by the Indian government at COP 26
Elsevier,
Cell Reports Physical Science, Volume 4, 16 August 2023
The demand for solar energy as a clean way to power human lives is increasing, but solar panels are land-intensive and may compete for space with farms. In this article, the authors examine how agrivoltaics (combining farming and solar technologies) can provide synergistic benefits together rather than in isolation, showing positive benefits in climate mitigation, climate resilience, and land equivalent ratios. This contributes to SDGs 2 (ensuring the promotion of sustainable agriculture), 7 (harnessing sunlight to power society), and 13 (agrivoltaics as a way to combat climate change).
