Elsevier,
SLAS Discovery, Volume 28, June 2023
In this study, a novel reporter substrate named C8CF3-coumarin was synthesized and then characterized, an assay protocol was developed to identify small molecular activators of PLCγ enzymes, and a proof-of-principle high throughput screen was conducted using PLCγ2 and the LOPAC1280 library. These studies showed that C8CF3-coumarin could indeed monitor PLCγ enzyme activity and identify potential small molecule activators from a screen. The identification of such small molecule PLCγ2 activators would be of great utility to the Alzheimer's disease research community by serving as both chemical probes to study the modulation of PLCγ2 and as potential therapeutic agents.
Elsevier,
Redox Biology, Volume 62, June 2023
SCFA contribute to the glutamate-glutamine shuttle by acting on glutamine synthetase. Long-term SCFA diet alleviates cognitive and spatial memory defeat in APP/PS1 mice. Long-term SCFA diet reduces Aβ deposition and abnormal phosphorylation of tau. SCFA promote astrocyte-neuron metabolic coupling to reduce oxidative damage.
Elsevier, The Lancet Regional Health - Southeast Asia, Volume 13, June 2023
Background: COVID-19 and the climate crisis have caused unprecedented disruptions across the world. Climate change has affected the mental health and wellbeing of children and adolescent. Young people with a mental illness and without social support are at an increased risk of climate change induced mental ill-health. COVID-19 resulted in a marked increase of psychological distress. Increase in depression, anxiety and insomnia have increased due to the upheavals that people were experiencing including loss of livelihood and breaking of social bonds.
Elsevier,
Geoderma Regional, Volume 33, June 2023
Castellanos-Barliza and León-Peláez 2023 investigated the recovery of physical-chemical and biological properties of Technosols in a chronosequence of drylands (over 7,10 and 21 years) in the El Cerrejón coal mine in Colombia. Their results showed significant improvements in soil properties, especially near the surface, with notable increases in soil N content and P solution after 7 years. Enhanced vegetation development over time contributed to higher soil organic matter, indicating successful rehabilitation and positive impacts of the restoration strategy in degraded mine spoils.
Elsevier,
One Earth, Volume 6, 16 June 2023
This article advances SDG # 13, 14, and 15 by arguing that ecosystem integrity is neglected but important for climate adaptation goals, and shows how linking ecosystem integrity to climate, biodiversity and sustainable development goals is crucial for optimal outcomes.
