Articles

This study provides evidence of distinct alterations in resting-state functional connectivity in individuals with amnestic mild cognitive impairment (aMCI) and late-life depression (LLD), underscoring region-specific vulnerabilities that may contribute to cognitive decline and depressive symptomatology in older adults.

The article describes the discovery and development of compound 8e, a selective and reversible butyrylcholinesterase (BuChE) inhibitor, as a potential therapeutic agent for treating Alzheimer's disease (AD). Compound 8e exhibited favorable blood-brain barrier permeability, good drug-likeness properties, and pronounced neuroprotective efficacy in various AD models, including zebrafish, scopolamine-induced mice, and APP/PS1 transgenic mice.

This study reports physiological stress in restored corals, highlighting the importance of coral microbiomes for conservation and restoration.

Big data shows significant potential for deep decarbonization in the transportation sector, while advances in artificial intelligence (AI) technologies help extracting valuable knowledge from such data. This study reviews the applications of big data and AI technologies in transportation, encompassing data accumulation, pattern understanding, and uncovering the intricate nexus between transportation activities and carbon emissions, ultimately providing insights for achieving carbon neutrality.