Articles

This research partnered with Aboriginal Elders to co-design and implement a 13-week online unit aimed at educating non-Indigenous health care providers on culturally respectful and safe dementia care for Aboriginal and Torres Strait Islander peoples. The involvement of Elders in guiding content, delivering weekly Zoom sessions, and evaluating students’ work was highly valued, leading to the unit’s recognition and availability nationally and internationally through the University of Tasmania.

The article investigates the role of CD38, an enzyme implicated in neuroinflammation and cellular senescence, in the context of vascular dementia (VaD). It demonstrates that inhibiting CD38 can mitigate cerebrovascular endothelial cell dysfunction, blood-brain barrier disruption, neuroinflammation, and white matter damage, ultimately alleviating cognitive impairment in a mouse model of VaD. The findings suggest that targeting CD38 may offer a promising therapeutic strategy for addressing the vascular and neurological deficits associated with VaD

A New Interactive Tool Empowers the Public to Search Geo-Targeted Missing Children Alerts Being Distributed Through the ADAM Program. The Dashboard Was Released in Honor of National Missing Children’s Day.

Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. Of these, 865 (43%) were previously reported, and 1,164 (57%) are novel.