Articles

This Research Paper supports SDGs 3 and 10 by investigating the contribution of multiple long-term conditions to the widening inequalities in disability-free life expectancy by socioeconomic deprivation.

Correspondence on the factors behind low COVID-19 immunisation coverage among marginalised communities in Latin America and the Caribbean, in the context of SDGs 3 and 10, highlighting the need to consider the specific circumstances of Indigenous communities in the development of national COVID-19 immunisation campaigns.

This article supports SDGs 7 and 9 by introducing interpretable artificial intelligence (AI) tools, especially proxy models based on artificial neural networks, efficient variable analysis and optimal value prediction of membrane electrode components in proton exchange membrane fuel cells, thereby improving their performance and reducing computational costs.

Niemann-Pick type C (NPC) disease, a lysosomal storage disorder caused by defective NPC1/NPC2 function, results in the accumulation of cholesterol and glycosphingolipids in lysosomes of affected organs, such as liver and brain. Moreover, increase of mitochondrial cholesterol (mchol) content and impaired mitochondrial function and GSH depletion contribute to NPC disease. However, the underlying mechanism of mchol accumulation in NPC disease remains unknown. As STARD1 is crucial in intramitochondrial cholesterol trafficking and acid ceramidase (ACDase) has been shown to regulate STARD1, we explored the functional relationship between ACDase and STARD1 in NPC disease.