Articles

The authors evaluated the quality and outcomes of in-hospital ACS management for White patients vs patients of colour, within a universal healthcare context.

We conducted a retrospective multicenter international analysis to identify prognostic factors, survival, and treatment-related outcomes in patients with HIV-BL contemporaneously treated. In this large collaborative effort, we analyzed a cohort of 249 patients with newly diagnosed HIV-BL treated at 35 centers in the United States and United Kingdom.

Alzheimer's disease (AD) is by far the most prevalent neurodegenerative disease of aging and is a major burden for patients, caregivers, and the overall health care system. The complexity of AD pathophysiology and the lack of deep understanding of disease mechanisms impeded the development of AD therapy. Currently approved treatments for AD only modestly improve cognitive function but do not modify disease course. The lack of pharmacological approaches has led to the consideration of alternative strategies to prevent or to slow down the progression of AD.

Background: Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures. Methods: In this modelling study, we collected time-series data on mortality and ambient temperatures from 750 locations in 43 countries and five meta-predictors at a grid size of 0·5° × 0·5° across the globe. A three-stage analysis strategy was used. First, the temperature–mortality association was fitted for each location by use of a time-series regression.