Microglia play a key role in innate immunity in Alzheimer disease (AD), but their role as antigen-presenting cells is as yet unclear. Here we found that amyloid β peptide (Aβ)-specific T helper 1 (Aβ-Th1 cells) T cells polarized to secrete interferon-γ and intracerebroventricularly (ICV) injected to the 5XFAD mouse model of AD induced the differentiation of major histocompatibility complex class II (MHCII)+ microglia with distinct morphology and enhanced plaque clearance capacity than MHCII− microglia.
Elsevier,
World Development, Volume 118, June 2019
Globally, industrial agriculture threatens critical ecosystem processes on which crop production depends, while 815 million people are undernourished and many more suffer from malnutrition. The second Sustainable Development Goal (SDG 2), Zero Hunger, seeks to simultaneously address global environmental sustainability and food security challenges. We conducted an integrated literature review organized around three disciplinary perspectives central to realizing SDG 2: ecology and agricultural sciences, nutrition and public health, and political economy and policy science.
3rd June 2019
This article highlights the winning proposals of the fourth edition of the Elsevier Foundation Green & Sustainable Chemistry Challenge. The winning proposals were chosen for their innovative green chemistry aspects and their large positive impact on the environment, contributing to SDGs 6, 13 and 15.
Elsevier, Journal of Hepatology, Volume 70, May 2019
Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years).
Elsevier, TrAC - Trends in Analytical Chemistry, Volume 114, May 2019
The presence of small plastic particles in the environment, reported for the first time in the 1970's, has only recently been recognized as a global issue. Although environmental awareness continues to grow, so does its consumption and associated risks. The number of studies reporting the presence of microplastics, has grown exponentially as did the concern over plastic degradation into smaller particles like nanoplastics, a potentially more pernicious form of plastic pollution.
Elsevier, Renewable and Sustainable Energy Reviews, Volume 105, May 2019
The Sustainable Development Goals and the Paris Agreement, as the two biggest climate action initiatives, address the need to shift towards a fully sustainable energy system. The deployment of renewable energy, especially solar and wind power, decreases carbon dioxide emissions, but presents issues of resource intermittency. In this study, a cost-optimised 100% renewable energy based system is analysed and quantified for the Americas for the reference year 2030 using high spatially and temporally resolved weather data.
Elsevier, International Journal of Hygiene and Environmental Health, Volume 222, May 2019
This study quantified antibiotic and antibiotic resistance gene (ARG) concentrations in hospital and communal wastewaters as well as the influents and effluents of the receiving urban wastewater treatment plants (UWWTP) in two Dutch cities. In only one city, hospital wastewater was treated on-site using advanced technologies, including membrane bioreactor treatment (MBR), ozonation, granulated activated carbon (GAC) and UV-treatment.
Currently, learning technologies are transforming and modifying educational systems with impressive progress of Information and Communication Technologies. Furthermore, when these technologies are available, accessible, usable and affordable, they represent more than just a transformation for people with disabilities, they represent real opportunities with access to an inclusive education and help to overcome the obstacles they meet in classical educational systems.
Elsevier, Research Policy, Volume 48, May 2019
To what extent is scientific research related to societal needs? To answer this crucial question systematically we need to contrast indicators of research priorities with indicators of societal needs. We focus on rice research and technology between 1983 and 2012. We combine quantitative methods that allow investigation of the relation between ‘revealed’ research priorities and ‘revealed’ societal demands, measured respectively by research output (publications) and national accounts of rice use and farmers’ and consumers’ rice-related needs.
