Elsevier,
The Lancet Global Health, Volume 11, August 2023
This Article supports SDG 3 by examining cost-effectiveness of implementing the HITSystem, a web-based intervention designed to improve outcomes of infants exposed to HIV, in Kenya. The study finds that HITSystem is among the most cost-effective early infant diagnosis interventions reported to date; the the cost per infant exposed to HIV was US$31·38 and the incremental cost-effectiveness ratio for life-years saved was $82·72.
Elsevier,
The Lancet Regional Health - Europe, Volume 31, August 2023
This Article supports SDG 3 by focusing on pregnant and postpartum women with HIV and assessing the risk factors for adverse postpartum outcomes and examining which factors can be addressed to support breastfeeding in resource-rich settings.
eClinicalMedicine, Volume 62, August 2023
Population-based surveys are expensive and time consuming. By determining state-level seropositivity using national testing service data and a Bayesian linear model, a map of HIV prevalence was generated across the whole of Nigeria. By identifying the areas in which HIV is most prevalent interventions can be targeted. This less resource intense Bayseian method allows for national monitoring of HIV prevalence.
Elsevier,
Engineering Applications of Artificial Intelligence, Volume 123, August 2023
Using brain tissue from donors with Alzheimer's disease, Anderson et al. identify new links between gene regulation and disease. These regulators could represent future clinical targets or disease markers for Alzheimer's diagnosis and treatment.
Elsevier,
Free Radical Biology and Medicine, Volume 204, 1 August 2023
In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.
The Lancet Regional Health - Southeast Asia, Volume 15, August 2023
The short comment supports SDGs 12 and 13 and advocates the concept of LIFE that focusses on an individual's responsibility to utilise resources mindfully and contribute their share to saving the planet. This concept was introduced by the Indian government at COP 26
