Elsevier,
Acta Pharmaceutica Sinica B, Volume , 2025
The article presents PI4AD, a computational medicine framework that integrates multi-omics data, systems biology, and artificial neural networks to prioritize therapeutic targets for Alzheimer's disease (AD). PI4AD recovers clinically validated targets like APP and ESR1, confirming its prioritization efficacy. The framework identifies Ras signaling as a central therapeutic hub, complementing traditional amyloid/tau-focused approaches. Crosstalk analysis reveals critical nodal genes (e.g., HRAS and MAPK1) and drug repurposing opportunities, bridging genetic insights with pathway-level biology.
Elsevier,
International Journal of Educational Research Open, Volume 8, June 2025, 100437
This study evaluates Child Aid’s innovative teacher training program in rural Guatemalan indigenous schools, which combines workshops, instructional coaching, and provision of children’s literature to enhance reading comprehension and critical thinking.
Elsevier, One-and Two-Dimensional Nanomaterials: Bioengineering Applications, Volume , 1 January 2025
Recent advances in nanotechnology have generated concerns regarding nanoparticles' prevalence, dispersion, destiny, and environmental migration. Nanoparticles originate from diverse sources, such as their extensive utilization in various engineering practices, biomedical uses, consumer products, and food and drug delivery systems. Nanoparticles and nanoscale materials are increasingly found in multiple environmental media, often released as waste or by-products from engineered processes.
Elsevier, Agriculture Toward Net Zero Emissions, Volume , 1 January 2025
Since 2016, there have been significant developments in agrivoltaic farming and the role of solar energy harvesting. The use of agrivoltaic farming applications differs between various countries due to challenges such as technical and economic ones. A short description of various solar panels has been presented. It discussed plant parameters for agrivoltaic system use, an especially possible role of light saturation point. Technical parameters for optimization of agrivoltaics—how various heights, spacing, impact of density the shading under the panels.
Elsevier, International Journal of Educational Research, Volume 132, January 2025
This qualitative study examines the role of outdoor science activities in improving students engagement with science subjects, finding that both teachers and students view them positively for enhancing motivation, collaboration, and long term learning. However, barriers such as limited teacher training, time constraints, and negative stakeholder perceptions highlight the need for targeted support and greater awareness to effectively integrate these approaches into science education.
Elsevier, International Journal of Educational Research, Volume 134, January 2025
This study examines whether conducting lessons in natural outdoor environments, rather than traditional classrooms, influences students conceptual learning. Results show that younger students benefited cognitively from outdoor lessons, while older students performed better indoors, although both groups perceived natural settings as more restorative, indicating that the physical environment can shape learning outcomes.
Elsevier,
Journal of Water Process Engineering, Volume 69, January 2025
Emerging pollutants (EPs), such as pharmaceuticals and personal care products (particularly antibiotics) and microplastics, pose significant threats to global water quality and human health, leading to increased interest in the use of constructed wetlands (CWs) for their purification. This paper reviews the literature from 2014 to 2024 on CWs' effectiveness in removing various EPs.
