Elsevier,
World Development, Volume 120, August 2019
The number of countries with a national development plan has more than doubled, from about 62 in 2006 to 134 in 2018. More than 80 per cent of the global population now lives in a country with a national development plan of one form or another. This is a stunning recovery of a practice that had been discredited in the 1980s and 1990s as a relic of directed economies and state-led development. Several factors have fostered this re-emergence but from about 2015 the momentum for producing plans has accelerated, driven in part by a need to plan for the Sustainable Development Goals (SDGs).
SLAS Discovery, Volume 24, 1 August 2019
High-throughput screening for drug discovery is increasingly utilizing cellular systems of high physiological relevance, such as patient primary cells and organoid cultures. We used 3D-cultured cystic fibrosis patient bronchial epithelial cells to screen for new small-molecule correctors of the disease-causing F508del mutation in CFTR. Impaired mucociliary clearance due to insufficient airway hydration is a hallmark of cystic fibrosis and we used a simple measure of surface liquid levels to quantify F508del CFTR correction in cultured bronchial epithelial cells. Two robust assay formats were configured and used to screen more than 100,000 compounds as mixtures or individual compounds in 96-well format. The corrector discovery success rate, as measured by the number of hits confirmed by an electrophysiology assay on patient primary bronchial epithelial cells, was superior to screens in cell lines expressing recombinant F508del CFTR. Several novel corrector scaffolds were discovered that when combined with the clinical corrector VX-809 delivered combination responses greater than double that of VX-809 alone. This work exemplifies the advantages of a disease-relevant readout and 3D-cultured patient primary cells for the discovery of new drug candidates.
Elsevier,
The Lancet Psychiatry, Volume 6, August 2019
This Commission supports SDG 3 by summarising advances in understanding on the topic of physical health in people with mental illness, and presents clear directions for health promotion, clinical care, and future research. The report describes how disparities could be reduced through evidence-based prescribing and better integration of physical and mental health care.
Elsevier, Journal of Experimental Social Psychology, Volume 83, July 2019
Decades of research indicate that the traits we ascribe to people often depend on their race. Yet, the bulk of this research has not considered how racial stereotypes might also depend on other aspects of targets’ identities. To address this, researchers have begun to ask intersectional questions about racial stereotypes, such as whether they are applied in similar ways to men and women, or to children and adults. In the present studies, we examine whether men who are described as gay (vs. not) become de-racialized in the minds of perceivers. That is, we test whether gay (vs.
Elsevier, Journal of Healthcare Quality Research, Volume 34, July - August 2019
Objective: To report various components of health system responsiveness among poor internal migrants who availed the government health facilities in 13 Indian cities. Materials and methods: Cluster random sampling was used to select 50,806 migrant households, of which 14,263 households avail the government health facility in last six months. In addition, 5072 women, who sought antenatal care and 3946 women who had delivery in government health facility during last six months were also included.
For seventy years, mass plastic production and waste mismanagement have resulted in huge pollution of the environment, including the marine environment. The first mention of seafood contaminated by microplastics was recorded in the seventies, and to date numerous studies have been carried out on shellfish, fish and crustaceans. Based on an ad hoc corpus, the current review aims to report on the numerous practices and methodologies described so far.
Elsevier, Veterinary Anaesthesia and Analgesia, Volume 46, July 2019
Objective: Attention is drawn to the potential of global warming to influence the health and wellbeing of the human race. There is increasing public and governmental pressure on healthcare organisations to mitigate and adapt to the climate changes that are occurring. The science of anaesthetic agents such as nitrous oxide and the halogenated anaesthetic agents such as greenhouse gases and ozone-depleting agents is discussed and quantified. Additional environmental impacts of healthcare systems are explored.
